Cep55/c10orf3 Mouse anti-Human, Clone: EMRC10-11-55, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9809-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278177

Quantity Price
1 £ 136.24 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Quantity 100μg
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Storage Requirements Store at 2-8°C.
Antigen Cep55/c10orf3
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Isotype IgG1
Format Purified
Host Species Mouse
Clone EMRC10-11-55
Gene Alias Centrosomal protein, c10orf3
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Primary or Secondary Primary
Regulatory Status RUO

The monoclonal antibody EMRC10-11-55 recognizes the human centrosomal protein (Cep55). Cep55 is a 55kDa microtubule-bundling protein that is found throughout the cell but specifically localizes to the mitotic spindle during metaphase and the midbody during anaphase. Cep55 is necessary for the completion of cytokenesis, a process that if disregulated promotes tumorigenesis via a mechanism of aneuploidy and chromosomal instablility. Cep55 is downstream of the transcription factor FOXM1, and has been found to be overexpressed in a head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, breast cancer, colorectal carcinoma (CRC), and in secondary metastatic sites. Expression has been found to correlate with severity of disease and as a cancer biomarker is prognostic of poor outcome in breast cancer. Cep55 is expressed at very modest levels in normal tissue, but is more prominent in testis and thymus.