Cep55/c10orf3 Mouse anti-Human, Clone: EMRC10-11-55, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9809-82

100UG:ANTI-HUMAN CEP55 PURIFIED 100 UG

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278177

Quantity Price
1 £ 163.0 / 100µg
Estimated Shipment date
from Supplier 23-01-2017
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Description and Specification

Specification

Antigen Cep55/c10orf3
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Clone EMRC10-11-55
Concentration 0.5mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Centrosomal protein, c10orf3
Host Species Mouse
Isotype IgG1
Quantity 100μg
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The monoclonal antibody EMRC10-11-55 recognizes the human centrosomal protein (Cep55). Cep55 is a 55kDa microtubule-bundling protein that is found throughout the cell but specifically localizes to the mitotic spindle during metaphase and the midbody during anaphase. Cep55 is necessary for the completion of cytokenesis, a process that if disregulated promotes tumorigenesis via a mechanism of aneuploidy and chromosomal instablility. Cep55 is downstream of the transcription factor FOXM1, and has been found to be overexpressed in a head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, breast cancer, colorectal carcinoma (CRC), and in secondary metastatic sites. Expression has been found to correlate with severity of disease and as a cancer biomarker is prognostic of poor outcome in breast cancer. Cep55 is expressed at very modest levels in normal tissue, but is more prominent in testis and thymus.