missing translation for 'onlineSavingsMsg'
Learn More

Cep55/c10orf3 Mouse anti-Human, Clone: EMRC10-11-55, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9809-82

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15278177

  • £136.24 / 100µg


Estimated Shipment
03-08-2017
Add to basket

Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody EMRC10-11-55 recognizes the human centrosomal protein (Cep55). Cep55 is a 55kDa microtubule-bundling protein that is found throughout the cell but specifically localizes to the mitotic spindle during metaphase and the midbody during anaphase. Cep55 is necessary for the completion of cytokenesis, a process that if disregulated promotes tumorigenesis via a mechanism of aneuploidy and chromosomal instablility. Cep55 is downstream of the transcription factor FOXM1, and has been found to be overexpressed in a head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, breast cancer, colorectal carcinoma (CRC), and in secondary metastatic sites. Expression has been found to correlate with severity of disease and as a cancer biomarker is prognostic of poor outcome in breast cancer. Cep55 is expressed at very modest levels in normal tissue, but is more prominent in testis and thymus.
Description & Specifications

Specifications

Cep55/c10orf3
EMRC10-11-55
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
Purified
Centrosomal protein, c10orf3
IgG1
RUO
Primary
Human