CEP55, clone: EMRC10-11-55, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-9809-82
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionDescription: The monoclonal antibody EMRC10-11-55 recognizes the human centrosomal protein (Cep55). Cep55 is a 55kDa microtubule-bundling protein that is found throughout the cell but specifically localizes to the mitotic spindle during metaphase and the midbody during anaphase. Cep55 is necessary for the completion of cytokenesis, a process that if disregulated promotes tumorigenesis via a mechanism of aneuploidy and chromosomal instablility. Cep55 is downstream of the transcription factor FOXM1, and has been found to be overexpressed in a head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, breast cancer, colorectal carcinoma (CRC), and in secondary metastatic sites. Expression has been found to correlate with severity of disease and as a cancer biomarker is prognostic of poor outcome in breast cancer. Cep55 is expressed at very modest levels in normal tissue, but is more prominent in testis and thymus.Applications Reported: This EMRC10-11-55 antibody has been reported for use in western blotting and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Applications Tested: This EMRC10-11-55 antibody has been tested by immunohistochemistry on FFPE human breast cancer tissue using low pH antigen retrieval at less than or equal to 10 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
|PBS with 0.09% sodium azide; pH 7.2|
|C10orf3, CT111, URCC6, cancer/testis antigen 111, centrosomal protein of 55 kDa, up-regulated in colon cancer 6|
|Store at 2-8°C.|
For Research Use Only.