CD96 (TACTILE) Mouse anti-Human, PerCP-eFluor 710, Clone: NK92.39, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-0969-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15549166

Quantity Price
1 £ 84.99 / 25 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Antigen CD96 (TACTILE)
Clone NK92.39
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Conjugate PerCP-eFluor 710
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.25μg)/test
Format Conjugated
Isotype IgG1
Applications Flow Cytometry
Quantity 25 tests
Host Species Mouse
Primary or Secondary Primary
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human

The NK92.39.1 monoclonal antibody reacts with human CD96 also known as TACTILE (T cells-activated increased late expression). CD96 is a type I membrane protein of the Immunoglobulin Superfamily. CD96 promotes NK cell adhesion to cells expressing the polio virus receptor (CD155). Therefore CD96 is an additional receptor for CD155. After binding of PVR to CD96, the PVR can be transferred to the target cell and CD96 can be internalized with bound PVR. This internalization may lead to cell death of the NK cell. This phenomenon may be significant in tumor cells which express high levels of PVR. Furthermore expression of CD96 has been found in the majority of CD34(+)CD38(-) Acute Myeloid Leukemic cells.)

The NK92.39.1 antibody can block binding of soluble CD155 to NK cell lines.