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CD93 (AA4.1), PE, clone: R3, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0938-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15566836

  • £68.96 / 25 tests


Estimated Shipment date
from Supplier 27-02-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The monoclonal antibody R3 recognizes human CD93, also known as C1qRp. The glycoprotein CD93 binds to C1q, the subunit of the complement protein, mannose binding lectin and pulmonary surfactant protein A. CD93 is predicted to play a role in the clearance of apoptotic cells. Expression of CD93 is confined to myeloid cells with higher expression on monocytes than neutrophils, eosinophils, platelets and endothelial cells. Expression on DC's is downregulated upon maturation. Additionally, CD93 has been shown to define an early bone marrow stem cell population of hematopoietic and hepatic precursors.The R3 antibody has been shown to have activating function by increasing phagocytosis when presented in an immobilized state and inhibitory functions when presented in a soluble state. CD93 can be shed from the cell surface. This phenomenon can be measures using R3 antibody as detection with R139 as capture to detect soluble CD93 by ELISA. The epitope for R3 lies in the CRD domain.\\The R3 antibody has been shown to have activating function by increasing phagocytosis when presented in an immobilized state and inhibitory functions when presented in a soluble state. CD93 can be shed from the cell surface. This phenomenon can be measures using R3 antibody as detection with R139 as capture to detect soluble CD93 by ELISA. The epitope for R3 lies in the CRD domain.Applications Reported: This R3 antibody has been reported for use in flow cytometric analysis.Applications Tested: This R3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD93
R3
PE
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
C1qRp, C1q Receptor, C1qR
IgM
RUO
Primary
Human
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