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CD93 (AA4.1) Monoclonal Antibody (AA4.1), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5892-85

162.67 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15249909

  • £244.00 / 500µg
Estimated Shipment: 08-05-2024
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Description

Description

Description: The AA4.1 monoclonal antibody reacts with mouse C1qRp, an approximately 130-140 kDa C-type lectin-like type I transmembrane protein. The AA4.1 antigen was originally identified as an antigen expressed on early stages of B cell development in bone marrow. Adult spleen and fetal liver also have detectable numbers of AA4.1^+ cells. In combination with other markers of hematopoietic progenitor cells such as Thy-1, Sca-1, c-Kit, CD43, and CD24, the bone marrow Lymphoid-Committed Progenitors (CLP) can be segregated into more primitive and more differentiated subsets based on expression of AA4.1. Correlated expression of surface IgM (sIgM), CD23, and AA4.1 antigen has also been used to define three nonproliferative subpopulations of immature/transitional peripheral B cells designated: T1 (AA4.1^+/CD23^-/sIgMhi), T2 (AA4.1^+/CD23^+/sIgMhi), and T3 (AA4.1^+/CD23^+/sIgMlo). AA4.1 is also reported to be expressed in cytoplasmic vesicles in endothelial cells, megakaryoblasts, and platelets. It is reported that monoclonal antibodies AA4.1 and 493 recognize different epitopes of the same molecule. Applications Reported: The AA4.1 antibody has been reported for use in flow cytometric analysis. Applications Tested: The AA4.1 antibody has been tested by flow cytometric analysis of mouse bone marrow and splenocyte cells. This can be used at less than or equal to 0.25 μg per test.

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
Specifications

Specifications

CD93 (AA4.1)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O89103
Cd93
Affinity chromatography
RUO
17064
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
AA4.1
Biotin
Cd93
6030404G09Rik; AA145088; Aa4; AA4.1; AW555904; C1q receptor; C1q receptor 1; C1q/MBL/SPA receptor; C1qR; C1qR(P); C1qr1; C1qRP; Cd93; CD93 antigen; CD93 molecule; CDw93; Cell surface antigen AA4; complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; ly-68; Lymphocyte antigen 68; matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4
Rat
500 μg
Primary
Mouse
Antibody
IgG2b κ
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