CD93 (AA4.1) Rat anti-Mouse, APC, Clone: AA4.1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5892-83

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15390770

Quantity Price
1 £ 217.47 / 200µg
EU Stock 2
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Description and Specification

Specification

Conjugate Allophycocyanin
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Clone AA4.1
Monoclonal or Polyclonal Monoclonal
Gene Alias C1qRp, Early B lineage antigen
Species Reactivity Mouse
Concentration 0.2mg/mL
Quantity 200μg
Isotype IgG2b
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD93 (AA4.1)
Format Conjugated
Primary or Secondary Primary
Host Species Rat

The AA4.1 monoclonal antibody reacts with mouse C1qRp, an approximately 130-140kDa C-type lectin-like type I transmembrane protein. The AA4.1 antigen was originally identified as an antigen expressed on early stages of B cell development in bone marrow. Adult spleen and fetal liver also have detectable numbers of AA4.1+ cells. In combination with other markers of hematopoietic progenitor cells such as Thy-1, Sca-1, c-Kit, CD43, and CD24, the bone marrow Lymphoid-Committed Progenitors (CLP) can be segregated into more primitive and more differentiated subsets based on expression of AA4.1. Correlated expression of surface IgM (sIgM), CD23, and AA4.1 antigen has also been used to define three nonproliferative subpopulations of immature/transitional peripheral B cells designated: T1 (AA4.1+/CD23-/sIgMhi), T2 (AA4.1+/CD23+/sIgMhi), and T3 (AA4.1+/CD23+/sIgMlo). AA4.1 is also reported to be expressed in cytoplasmic vesicles in endothelial cells, megakaryoblasts, and platelets. It is reported that monoclonal antibodies AA4.1 and 493 recognize different epitopes of the same molecule.