CD9 Rat anti-Mouse, Clone: eBioKMC8 (KMC8), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0091-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15286787

Quantity Price
1 £ 152.25 / 500µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Isotype IgG2a
Applications Flow Cytometry
Applications Western Blotting
Primary or Secondary Primary
Gene Alias MIC3, Tspan29
Antigen CD9
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 500μg
Concentration 0.5mg/mL
Clone eBioKMC8 (KMC8)
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Format Purified
Host Species Rat

The eBioKMC8 monoclonal antibody reacts with mouse CD9, a 24kDa member of the transmembrane 4 superfamily. This family is characterized by the presence of four hydrophobic domains spanning the cell membrane and short N- and C-terminal cytoplasmic domains. CD9 is expressed by several cell types including monocytes, macrophages, platelets, early B cells, activated B and T cells, dendritic cells, eosinophils, basophils, endothelial cells, myoblasts and neuroblasts. On T cells, CD9 functions as a co-stimulatory molecule on naïve T cells. Furthermore, CD9 is expressed in oocytes, and CD9-deficiency results in sterility caused by defective gamete fusion. In mouse macrophages, CD9 functionally associates with FcγRs to modify signals for phagocytosis and inflammatory responses. In mouse B cells, it was discovered that CD9 is a marker for marginal zone B cells, B1 cells, and plasma cells. In dendritic cells, recently it was demonstrated that CD9 facilitates the association of heterologous MHC II molecules. The level of CD9 expression is subject to donor variability.