CD9 Mouse anti-Human, Biotin, Clone: eBioSN4 (SN4 C3-3A2), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0098-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15101797

Quantity Price
1 £ 48.31 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Host Species Murine
Applications Flow Cytometry
Concentration 0.5mg/mL
Conjugate Biotin
Monoclonal or Polyclonal Monoclonal
Antigen CD9
Primary or Secondary Primary
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 25μg
Clone eBioSN4 (SN4 C3-3A2)
Isotype IgG1
Species Reactivity Human
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze.
Gene Alias MIC3, MRP-1

The eBioSN4 monoclonal antibody reacts with human CD9. CD9 is a 24kDa member of the tetraspanin family, whose members are characterized by the presence of 4 hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells and neural cell lines. Furthermore, CD9 expression has been associated with a malignant phenotype, including expression on 90% of non T cell acute lymphoblastic leukemia cells and on 50% of chronic lymphocytic and acute myeloblastic leukemias. In platelets, CD9 is expressed in α-granules and through association with the integrin αIIb/βIII plays a role in platelet aggregation, as demonstrated by the use of anti-human CD9 antibodies. CD9 has also been shown to induce the aggregation of pre-B cell lines, and the adhesion and migration of pre-B cells and Schwann cells. Additionally, it has been demonstrated that CD9 is able to provide a co-stimulatory signal for T cells independently of CD28, in the absence of antigen-presenting cells. Binding of the eBioSN4 monoclonal antibody partially cross-blocks binding of another anti-human CD9 monoclonal antibody, MM2/57.