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CD9 Mouse anti-Human, Biotin, Clone: eBioSN4 (SN4 C3-3A2), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0098-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15101797

  • £48.31 / 25µg


Estimated Shipment date
from Supplier 22-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBioSN4 monoclonal antibody reacts with human CD9. CD9 is a 24kDa member of the tetraspanin family, whose members are characterized by the presence of 4 hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells and neural cell lines. Furthermore, CD9 expression has been associated with a malignant phenotype, including expression on 90% of non T cell acute lymphoblastic leukemia cells and on 50% of chronic lymphocytic and acute myeloblastic leukemias. In platelets, CD9 is expressed in α-granules and through association with the integrin αIIb/βIII plays a role in platelet aggregation, as demonstrated by the use of anti-human CD9 antibodies. CD9 has also been shown to induce the aggregation of pre-B cell lines, and the adhesion and migration of pre-B cells and Schwann cells. Additionally, it has been demonstrated that CD9 is able to provide a co-stimulatory signal for T cells independently of CD28, in the absence of antigen-presenting cells. Binding of the eBioSN4 monoclonal antibody partially cross-blocks binding of another anti-human CD9 monoclonal antibody, MM2/57.
Specifications

Specifications

CD9
eBioSN4 (SN4 C3-3A2)
Biotin
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
MIC3, MRP-1
IgG1
RUO
Primary
Human