CD8b Mouse anti-Rat, FITC, Clone: eBio341 (341), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-0080-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15248009

Quantity Price
1 £ 54.42 / 50µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Regulatory Status RUO
Primary or Secondary Primary
Gene Alias CD8 beta, Ly-3
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Mouse
Isotype IgG1
Quantity 50μg
Clone eBio341 (341)
Format Conjugated
Antigen CD8b
Species Reactivity Rat
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate FITC

The eBio341 monoclonal antibody reacts with rat CD8β. CD8β is a member of the immunoglobulin superfamily which heterodimerizes with CD8α to form the CD8 antigen expressed on CD4+CD8+, double-positive thymocytes, the majority of MHC class I-restricted peripheral T cells, and on some macrophages. CD8β expression is absent in athymic mice, which are populated by T-cells expressing CD8α homodimers. This has led to the idea that CD8β expression is dependent on the development of T cells in the thymus. CD8 binds to MHC class I expressed on the surface of antigen-presenting cells during antigen presentation, and participates in T-cell receptor signal transduction through association with the kinase Lck.