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CD8a Rat anti-Mouse, Biotin, Clone: 4SM15, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0808-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587316

  • £186.31 / 100µg


EU Stock 1
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Disclaimers:

For Research Use Only.


Specifications

Description

The 4SM15 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.

Recent studies have shown the 4SM15 antibody recognizes and binds a non-CD8a epitope in neural tissue. The 4SM15 clone is not recommended for staining of mouse neural tissue. For additional information please contact our technical service (tech@eBioscience.com).

The 4SM15 monoclonal antibody is not recommended for immunohistochemistry of frozen mouse tissue. For detection of mouse CD8a using immunohistochemistry of frozen tissue please refer to alternate product Anti-Mouse CD8a Purified (cat. 14-0081).
Description & Specifications

Specifications

CD8a
4SM15
Biotin
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze.
Monoclonal
Microscopy
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
CD8 alpha, Ly-2, Ly-35, Lyt-2
IgG2a
RUO
Primary
Murine