CD8a Rat anti-Mouse, Alexa Fluor 488, Clone: 53-6.7, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-0081-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15321980

Quantity Price
1 £ 60.53 / 25µg
Estimated Shipment date
from Supplier 10-05-2017
Add to basket


Description and Specification

Specification

Antigen CD8a
Host Species Rat
Isotype IgG2a
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Alexa Fluor 488
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Monoclonal or Polyclonal Monoclonal
Quantity 25μg
Primary or Secondary Primary
Species Reactivity Mouse
Format Conjugated
Applications Flow Cytometry
Regulatory Status RUO
Concentration 0.5mg/mL
Clone 53-6.7

The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.