CD8a Rat anti-Mouse, Alexa Fluor 488, Clone: 53-6.7, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-0081-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15331980

Quantity Price
1 £ 121.67 / 100µg
EU Stock 2
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Species Reactivity Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Applications Flow Cytometry
Conjugate Alexa Fluor 488
Isotype IgG2a
Clone 53-6.7
Concentration 0.5mg/mL
Host Species Rat
Gene Alias CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Antigen CD8a
Quantity 100μg

The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.