CD8a Mouse anti-Human, eFluor 450, Clone: OKT8 (OKT-8), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-0086-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15559626

Quantity Price
1 £ 167.38 / 100 tests
EU Stock 8
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Description and Specification

Specification

Host Species Murine
Quantity 100 Tests
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Gene Alias CD8 alpha, leu-2a
Primary or Secondary Primary
Concentration 5μL (0.125μg)/test
Conjugate eFluor 450
Applications Flow Cytometry
Isotype IgG2a
Clone OKT8 (OKT-8)
Antigen CD8a
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.