CD8a Mouse anti-Human, Alexa Fluor 488, Clone: OKT8, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-0086-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15500187

Quantity Price
1 £ 91.11 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Concentration 5μL (0.06μg)/test
Quantity 25 tests
Regulatory Status RUO
Conjugate Alexa Fluor 488
Antigen CD8a
Applications Flow Cytometry
Isotype IgG2a
Primary or Secondary Primary
Host Species Mouse
Clone OKT8 (OKT-8)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Gene Alias CD8 alpha, leu-2a
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.