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CD86 (B7-2) Rat anti-Mouse, PE, Clone: PO3.1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0861-81

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15288599

  • £61.11 / 50µg


Estimated Shipment date
from Supplier 27-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The PO3.1 monoclonal antibody reacts with mouse CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.
Specifications

Specifications

CD86 (B7-2)
PO3.1
PE
Conjugated
Rat
50μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
B72, B7.2, B70, Ly-58
IgG2b
RUO
Primary
Murine