CD86 (B7-2) Rat anti-Mouse, Clone: PO3.1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0861-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258517

Quantity Price
1 £ 182.82 / 500µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Conjugate Unlabeled
Isotype IgG2b
Regulatory Status RUO
Gene Alias B70, Ly-58
Concentration 1mg/mL
Primary or Secondary Primary
Quantity 500μg
Antigen CD86 (B7-2)
Formulation aqueous buffer, no sodium azide
Host Species Rat
Format Purified
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Clone PO3.1
Applications Flow Cytometry
Applications Functional Assay
Monoclonal or Polyclonal Monoclonal

The PO3.1 monoclonal antibody reacts with mouse CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.