CD86 (B7-2) Mouse anti-Human, Clone: IT2.2, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0869-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15208527

Quantity Price
1 £ 66.65 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Species Reactivity Human
Concentration 1mg/mL
Conjugate Unlabeled
Host Species Mouse
Primary or Secondary Primary
Isotype IgG2b
Monoclonal or Polyclonal Monoclonal
Clone IT2.2
Format Purified
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Gene Alias B72, B70
Quantity 50μg
Antigen CD86 (B7-2)
Formulation aqueous buffer, no sodium azide
Storage Requirements Store at 2-8°C.

The IT2.2 monoclonal antibody reacts with human CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.