CD86 (B7-2) Mouse anti-Human, Biotin, Clone: IT2.2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0869-80

Product Code. 15269639

Disclaimers:

For Research Use Only.

Description

The IT2.2 monoclonal antibody reacts with human CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.

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Specifications

• Antigen: CD86 (B7-2)
• Clone: IT2.2
• Conjugate: Biotin
• Format: Conjugated
• Host Species: Murine
• Quantity: 25μg
• Storage Requirements: Store at 2-8°C. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Concentration: 0.5mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: B72, B70
• Isotype: IgG2b
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human