CD86 (B7-2) Mouse anti-Human, Alexa Fluor 488, Clone: IT2.2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 53-0869-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15580187

Quantity Price
1 £ 74.51 / 25 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Species Reactivity Human
Regulatory Status RUO
Isotype IgG2b
Format Conjugated
Primary or Secondary Primary
Gene Alias B72, B70
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.25μg)/test
Conjugate Alexa Fluor 488
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Clone IT2.2
Quantity 25 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD86 (B7-2)

The IT2.2 monoclonal antibody reacts with human CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.