CD85k (ILT3) Mouse anti-Human, APC, Clone: ZM4.1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5139-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15518116

Quantity Price
1 £ 91.11 / 25 tests
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Clone ZM4.1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Quantity 25 tests
Antigen CD85k (ILT3)
Isotype IgG1
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias LIR5, LILRB4, HM18, GM 4d
Applications Flow Cytometry
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Conjugate APC
Regulatory Status RUO
Primary or Secondary Primary
Concentration 5μL (0.125μg)/test

The monoclonal antibody ZM4.1 recognizes ILT3, also known as CD85k. ILT3 is a member of the large family of ILT molecules (Immunologulin-like Transcripts, Leucocyte Ig-like Receptors (LIRs) and Monocyte/Macrophage Ig-like Receptors (MIRs). ILT3 is a 60kDa transmembrane protein with two Ig domains and ITIMs. Expression is found on monocytes, macrophages, and dendritic cells. High levels of ILT3 expression is also found on plasmacytoid dendritic cells (pDCs). ILT3 expression by DCs has been shown to be required to induce Regulatory Tcells (tregs). Addition of ZM4.1, like ZM3.8, blocks the suppressive function of the Tregs in in vitro culture systems with allogenic DC’s.