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CD85j (ILT2) Mouse anti-Human, APC, Clone: HP-F1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-5129-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15598106

  • £84.99 / 25 tests


EU Stock 1
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody HP-F1 recognizes CD85j, also known as ILT2, LILRB1, and LIR1. CD85j is a member of the ILT (immunoglobulin-like transcript)/LIR (leukocyte Ig-like receptor)/MIR (monocyte Ig-like receptor) family. CD85j is a single transmembrane glycoprotein with a long cytoplasmic domain containing 4 ITIMs which signal through interactions with SHP-1. Expression is found on myeloid cells (monocytes and dendritic cells) and some lymphoid cells including, subsets of NK, T and B cells. Expression has been correlated with leukemias such as ALL and CLL. Expression on CD8+ cells correlates with effector cell function and plays an important role in viral infections, including HIV, Ebstein Barr and CMV. The ligands for CD85j are MHC Class I molecules such as HLA-G, A, F, B27, E and F.

The monoclonal antibody HP-F1 has been shown to reduce the amount of CD16- dependent cytolytic activity of functional NK cells.
Specifications

Specifications

CD85j
HP-F1
APC
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
LIR1, LILRB1, MIR7
IgG1
RUO
Primary
Human
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