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CD85g (ILT7) Mouse anti-Human, PE, Clone: eBio17G10.2 (17G10.2), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-5179-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15596996

  • £84.99 / 25 tests


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For Research Use Only.


Description

Description

The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 is part of the leukocyte immunoglobulin-like receptor (LIR) gene family and associates with Fc epsilon R1 gamma to form a functional complex which transduces ITAM-mediated signals that negatively modulates TLR-induced type I IFN production by human plasmacytoid dendritic cells. ILT7 is expressed exclusively on plasmacytoid dendritic cells and is absent in monocyte derived DCs. Treatment with IL-3 or CpG causes a decrease in expression.

Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 yields virtually complete co-staining. Cross linking of ILT7 with eBio17G10.2 antibody causes reduced transcription of IFN alpha1, IFN alpha2, IFN alpha4 and IFN beta.
Specifications

Specifications

CD85g (ILT7)
eBio17G10.2 (17G10.2)
PE
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ILT-7, LILRA4
IgG1
RUO
Primary
Human
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