CD85g (ILT7) Mouse anti-Human, APC, Clone: 17G10.2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-5179-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15568116

Quantity Price
1 £ 152.25 / 100 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Antigen CD85g (ILT7)
Format Conjugated
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate APC
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone eBio17G10.2 (17G10.2)
Quantity 100 tests
Isotype IgG1
Applications Flow Cytometry
Species Reactivity Human
Host Species Mouse
Concentration 5μL (0.25μg)/test

The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 is part of the leukocyte immunoglobulin-like receptor (LIR) gene family and associates with FcεR1γ to form a functional complex which transduces ITAM-mediated signals that negatively modulates TLR-induced type I IFN production by human plasmacytoid dendritic cells. ILT7 is expressed exclusively on plasmacytoid dendritic cells and is absent in monocyte derived DCs. Treatment with IL-3 or CpG causes a decrease in expression.

Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 yields virtually complete co-staining. Cross linking of ILT7 with eBio17G10.2 antibody causes reduced transcription of IFN-α1, IFN-α2, IFN-α4 and IFN-β.