missing translation for 'onlineSavingsMsg'
Learn More

CD85d (ILT4) Rat anti-Human, FITC, Clone: 27D6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-5148-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15536556

  • £115.56 / 100 tests


EU Stock 9
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody 27D6 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leuokocyte Ig-like receptor) MIR (monocytes Ig-like receptor) family. CD85d is a 110kDa single transmembrane receptor containing 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection.

The monoclonal antibody 27D6 has been shown to block binding of ligand (HLA-G tetramer).
Specifications

Specifications

CD85d
27D6
FITC
Conjugated
Rat
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ILT-4, LIR2, LILRB2, MIR10
IgM
RUO
Primary
Human
Videos