CD85d (ILT4) Rat anti-Human, FITC, Clone: 27D6, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-5148-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15526556

Quantity Price
1 £ 60.53 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Quantity 25 Tests
Monoclonal or Polyclonal Monoclonal
Isotype IgM
Regulatory Status RUO
Format Conjugated
Clone 27D6
Primary or Secondary Primary
Gene Alias ILT-4, LIR2, LILRB2, MIR10
Concentration 5μL (0.5μg)/test
Antigen CD85d (ILT4)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Conjugate FITC
Host Species Rat
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The monoclonal antibody 27D6 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leuokocyte Ig-like receptor) MIR (monocytes Ig-like receptor) family. CD85d is a 110kDa single transmembrane receptor containing 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection.

The monoclonal antibody 27D6 has been shown to block binding of ligand (HLA-G tetramer).