CD8 Mouse anti-Human, Biotin, Clone: OKT8 (OKT-8), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0086-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15219439

Quantity Price
1 £ 109.45 / 100µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Antigen CD8
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Isotype IgG2a
Species Reactivity Human
Format Conjugated
Regulatory Status RUO
Gene Alias CD8 alpha, leu-2a
Concentration 0.5mg/mL
Conjugate Biotin
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze.
Quantity 100μg
Clone OKT8 (OKT-8)
Primary or Secondary Primary

The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.