Epredia™ Lab Vision™ CD8 Ab-1, Mouse Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ CD8 Ab-1, Mouse Monoclonal Antibody.

Product Code	Brand	Form	Quantity
12601497	Epredia™ MS-457-S0	Concentrated	100 μL
12631497	Epredia™ MS-457-S1	Concentrated	500 μL
12621497	Epredia™ MS-457-S	Concentrated	1 mL
12611497	Epredia™ MS-457-R7	Prediluted	7 mL

Description

CD8 molecule consists of two chains, termed α and Β chain, which are expressed as a disulphide-α β heterdimer or as an alpha α homodimer on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells. The majority of CD8+ Tcells expresses CD8 as αβheterodimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not Β chain).

Host Species: Mouse

Clone: C8/144B

Isotype: IgG1/κ

Species Reactivity: Human. Does not react with rat. Others not known.

Epitope: C-terminal

Immunogen: A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of α-chain of human CD8 molecule

Molecular Weight: 32 kDa

Positive Control: Lymph node or tonsil

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

General References:

1. Mason DY, et. al. Journal of Clinical Pathology, 1992, 45(12):1084-8.

Specifications

• Antigen: CD8 Ab-1
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: T-Cell
• Immunogen: A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of alpha chain of human CD8 molecule

• Clone: C8/144B
• Conjugate: Unconjugated
• Regulatory Status: IVD
• Target Species: Human
• Primary or Secondary: Primary