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CD79a Mouse anti-Mouse, eFluor 660, Clone: 24C2.5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-0791-82

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15381870

  • £182.82 / 100µg


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For Research Use Only.


Description

Description

This 24C2.5 monoclonal antibody reacts with the intracellular tail of mouse CD79a (also known as Ig alpha or mb-1), a signaling component of the B cell receptor (BCR). CD79a heterodimerizes with CD79b (Ig beta, B29), and together with surface Ig, make up the BCR. Both CD79 subunits consist of a single extracellular Ig domain, a transmembrane domain, and an intracellular signaling domain. CD79a is expressed almost exclusively on B cells, as well as in most B lineage acute lymphoblastic leukemias. The cytoplasmic domain of CD79a contains immunoreceptor tyrosine-based activation motifs (ITAMs), which constitute the signal transducing portions of the BCR. Tyrosine phosphorylation of these ITAMs by Syk and Lyn initiates numerous signaling cascades, resulting in B cell activation, proliferation, and differentiation.
Specifications

Specifications

CD79a
24C2.5
eFluor 660
Conjugated
Murine
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Ig-alpha, mb-1, Ly-54
IgG1
RUO
Primary
Murine
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