CD74 Mouse anti-Human, FITC, Clone: 5-329, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-0748-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586446

Quantity Price
1 £ 127.8 / 100 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Host Species Murine
Quantity 100 Tests
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Clone 5-329
Antigen CD74
Gene Alias Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration Inhibitory Factor
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test
Applications Flow Cytometry
Isotype IgG1
Primary or Secondary Primary
Conjugate FITC
Species Reactivity Human
Format Conjugated

This 5-329 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFκB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.