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CD74 Mouse anti-Human, FITC, Clone: 5-329, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-0748-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586446

  • £127.80 / 100 tests


Estimated Shipment date
from Supplier 27-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This 5-329 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFκB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.
Specifications

Specifications

CD74
5-329
FITC
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration Inhibitory Factor
IgG1
RUO
Primary
Human