CD74 Mouse anti-Human, Clone: VIC-Y1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0747-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15207077

Quantity Price
1 £ 66.65 / 100µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD74
Format Purified
Clone VIC-Y1
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Species Reactivity Human
Regulatory Status RUO
Primary or Secondary Primary
Conjugate Unlabeled
Quantity 100μg
Storage Requirements Store at 2-8°C.
Applications Immunohistochemistry (Formalin/Paraffin)
Isotype IgG1
Concentration 0.5mg/mL

This VIC-Y1 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFkB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.

The VIC-Y1 monoclonal antibody binds to a cytoplasmic region of human CD74 and thus cannot be used to detect cell surface expression of this molecule.