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CD74 Mouse anti-Human, Clone: VIC-Y1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0747-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15207077

  • £66.65 / 100µg


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Disclaimers:

For Research Use Only.


Description

Description

This VIC-Y1 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFkB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.

The VIC-Y1 monoclonal antibody binds to a cytoplasmic region of human CD74 and thus cannot be used to detect cell surface expression of this molecule.
Specifications

Specifications

CD74
VIC-Y1
Unconjugated
Purified
IgG1
RUO
Primary
Human
Immunohistochemistry (Formalin/Paraffin)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal
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