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CD73 Mouse anti-Human, APC, Clone: AD2, eBioscience™

Mouse Monoclonal Antibody

£87.25 - £203.00

Specifications

Antigen CD73
Clone AD2
Target Species Human
Conjugate APC
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15597966
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Affymetrix eBioscience
17-0739-41
25 Tests £87.25
25 tests View alternative products
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Estimated Shipment
03-11-2020
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13298219
View Documents
Affymetrix eBioscience
17-0739-42
100 Tests £203.00
Each View alternative products
Save Up to 
»
Estimated Shipment
02-11-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations. Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been found.
Specifications

Specifications

CD73
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
AD2
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.