CD71 (Transferrin Receptor), PerCP-eFluor™ 710, clone: R17217 (RI7 217.1.4), eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 46-0711-80
Code : Z2
Additional Details : Weight : 0.25000kg
DescriptionFixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488 nm; Emission: 710 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregcy, irritable bowel syndrome and in HIV patients.
|CD71 (Transferrin Receptor)|
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1|
|R17217 (RI7 217.1.4)|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.