CD68 Rat anti-Mouse, PE, Clone: FA-11, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-0681-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15546816

Quantity Price
1 £ 74.51 / 25µg
EU Stock 8
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Description and Specification

Specification

Isotype IgG2a
Format Conjugated
Primary or Secondary Primary
Clone FA-11
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD68
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 25μg
Gene Alias macrosialin, gp110
Species Reactivity Mouse
Conjugate PE
Monoclonal or Polyclonal Monoclonal
Concentration 0.2mg/mL
Host Species Rat
Regulatory Status RUO
Applications Flow Cytometry (Intracellular Staining)

This FA-11 monoclonal antibody reacts with mouse CD68, known also as macrosialin. CD68 is a heavily O- and N- glycosylated type I integral membrane protein belonging to the sialomucin family and is closely related to the Lysosomal/endosomal-Associated Membrane Glycoproteins (LAMP). Although commonly used as a pan-macrophage marker, low levels of expression have also been observed in Langerhans cells and conventional dendritic cells. CD68 is mostly localized in the late endosomes and lysosomes with a smaller fraction circulating to the cell surface. In the steady state, only about 10-15% of CD68 is present at the surface. Cell stimulation increases expression of CD68, its transport to cell surface, and results in glycoform remodeling. CD68 binds oxidized LDL and is involved in the process of phagocytosis.