CD68 Rat anti-Mouse, Clone: FA-11, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0681-82

100UG Anti-Mouse CD68 Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15537426

Quantity Price
1 £ 185.4 / 100µg
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry (Frozen)
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG2a
Quantity 100μg
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Antigen CD68
Gene Alias macrosialin, gp110
Host Species Rat
Regulatory Status RUO
Species Reactivity Mouse
Clone FA-11
Concentration 0.5mg/mL
Conjugate Unlabeled

This FA-11 monoclonal antibody reacts with mouse CD68, known also as macrosialin. CD68 is a heavily O- and N- glycosylated type I integral membrane protein belonging to the sialomucin family and is closely related to the Lysosomal/endosomal-Associated Membrane Glycoproteins (LAMP). Although commonly used as a pan-macrophage marker, low levels of expression have also been observed in Langerhans cells and conventional dendritic cells. CD68 is mostly localized in the late endosomes and lysosomes with a smaller fraction circulating to the cell surface. In the steady state, only about 10-15% of CD68 is present at the surface. Cell stimulation increases expression of CD68, its transport to cell surface, and results in glycoform remodeling. CD68 binds oxidized LDL and is involved in the process of phagocytosis.

The FA-11 antibody is not recommended for use in immunohistochemistry of formalin-fixed paraffin embedded tissues.