CD68 Mouse anti-Human, Biotin, Clone: 815CU17, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0687-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15567316

Quantity Price
1 £ 117.89 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
Add to basket


Description and Specification

Specification

Format Conjugated
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone 815CU17
Concentration 0.5mg/mL
Isotype IgG1
Conjugate Biotin
Quantity 100μg
Antigen CD68
Regulatory Status RUO
Host Species Mouse
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze.

This 815CU17 monoclonal antibody reacts with human CD68, a 110 kDa, transmembrane glycoprotein that belongs to the sialomucin family and is closely related to the lysosomal-associated membrane proteins (LAMP) and scavenger receptor. CD68 is predominantly an intracellular protein, found mainly in the late endosomal compartment but can be detected in smaller amounts on the surface of mainly myeloid-derived cells: monocytes, macrophages, dendritic cells (and in some langerhans cells), neutrophils, basophils, mast cells, myeloid progenitor cells, and a subset of CD34+ hematopoietic bone marrow progenitor cells. The function has not been fully elucidated but based on homology and structure, CD68 may play a role in antigen processing or presentation and protection of the lysosomal membrane from hydrolytic enzymes. Reports have also shown expression in activated T cells, and about 40% of peripheral blood B lymphocytes and 50% of all B-ALL.

This 815CU17 antibody does not cross-react with mouse or rat CD68.

For flow cytometric analysis of human CD68, we recommend clone eBioY1/82A.