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CD66a (CEACAM1), clone: CC1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0661-80

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15267047

  • £55.74 / 25µg


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Description

Description

Description: The monoclonal antibody CC1 recognizes CD66a, also known as carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), biliary glycoprotein, and BPG. Expression of CD66a is found on brush borders, epithelial, and endothelial cells. In hematopoietic cells expression is found abundantly on B cells, as well as some NKs, monocytes, DCs, and granulocytes. Although low levels of mRNA have been identified in T cells in humans, resting mouse T lymphocytes are not reported to express CD66a, as confirmed by lack of staining with CC1 antibody. In humans, expression levels of CD66a have been used to identify malignancies. CD66a plays a key role as a regulator of BCR activation of B lymphocytes. An alternate allele, CEACAM1b, is expressed in SJL mice; therefore, CC1 does not stain SJL tissue. The monoclonal CC1 has been shown to block viral infection and also enhance B cell proliferation when combined with IgM crosslinking.Applications Reported: This CC1 antibody has been reported for use in flow cytometric analysis, and immunohistology staining of paraffin embedded tissue sections.Applications Tested: This CC1 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD66a (CEACAM1)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P31809
BGP, BGP1, BGPI, CD66a antigen, antigen CD66, carcinoembryonic antigen-related cell adhesion molecule 1
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Immunohistochemistry
CC1
Unconjugated
Ceacam1
Purified
Ceacam1
IgG1
25μg
Store at 2-8°C.
Primary
26365
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