CD61 (Integrin beta 3) Mouse anti-Human, APC, Clone: VI-PL2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0619-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15557956

Quantity Price
1 £ 164.47 / 100 tests
EU Stock 5
Add to basket


Description and Specification

Specification

Quantity 100 Tests
Conjugate Allophycocyanin
Host Species Murine
Concentration 5μL (0.25μg)/test
Clone VI-PL2
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Gene Alias ITGB3
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Isotype IgG1
Regulatory Status RUO
Applications Flow Cytometry
Format Conjugated
Species Reactivity Baboon, Canine, Cynomolgus, Human, Rhesus Ma
Antigen CD61 (Integrin beta 3)
Primary or Secondary Primary

The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.

This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.