CD6 Rat anti-Mouse, Clone: IM348, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0061-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15276767

Quantity Price
1 £ 60.53 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Quantity 100μg
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Antigen CD6
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Format Purified
Clone IM348
Isotype IgG2a
Host Species Rat
Species Reactivity Mouse
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled

The monoclonal antibody IM348 recognizes mouse CD6, a transmembrane glycoprotein of the scavenger receptor family. The extracellular domain contains three scavenger receptor cysteine rich (SRCR) domains, a transmembrane region and a cytoplasmic domain of variable length depending on the isoform. CD6 is expressed on most T lymphocytes. Expression between human and mouse is slightly different. In mice B cells in the spleen do not have CD6, while humans express it on a subset of B lymphocytes. The CD6 ligand is CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM). Through interactions with CD166 or homotypic CD6-CD6, a role exists in adhesion and migration during organogenesis. The intracellular domain of CD6 is constitutively phosphorylated, suggesting a role in T cell activation and signaling. In humans depletion of CD6-expressing cells increases graft versus host tolerance in transplants.