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CD59 (Protectin) Mouse anti-Human, PE, Clone: OV9A2, eBioscience™

Mouse Monoclonal Antibody

£59.00 - £142.00

Specifications

Antigen CD59 (Protectin)
Clone OV9A2
Target Species Human
Conjugate PE
Isotype IgG1, kappa
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15576796
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Affymetrix eBioscience
12-0596-41
25 Tests £59.00
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Estimated Shipment
02-11-2020
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15586796
View Documents
Affymetrix eBioscience
12-0596-42
100 Tests £142.00
100 tests View alternative products
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»
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Description

Description

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
Specifications

Specifications

CD59 (Protectin)
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
OV9A2
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.