CD59 (Protectin) Mouse anti-Human, PE, Clone: OV9A2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-0596-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586796

Quantity Price
1 £ 128.38 / 100 tests
EU Stock 15
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Description and Specification

Specification

Conjugate PE
Format Conjugated
Species Reactivity Human
Clone OV9A2
Regulatory Status RUO
Gene Alias MIRL
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.125μg)/test
Isotype IgG1
Quantity 100 tests
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Host Species Mouse
Applications Flow Cytometry
Antigen CD59 (Protectin)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

This OV9A2 monoclonal antibody reacts with human CD59, which is also known as Protectin. This GPI-linked membrane glycoprotein shares structural homology with the murine Ly-6 superfamily. CD59 is expressed on all human lymphocytes, monocytes, granulocytes, and erythrocytes. This protein is also expressed on non-hematopoietic cells, including endothelial cells and neurons. By binding the complement components C8 and C9, CD59 inhibits assembly of the membrane attack complex and cytolytic activity by complement. CD59 interacts with CD2 to modulate T cell adhesion, and also plays a role in T cell activation. Finally, altered expression of CD55 and CD59 on human peripheral blood cells has been observed in patients with systemic lupus erythematosus (SLE).

Crossblocking studies indicate that the OV9A2 monoclonal antibody binds the same epitope as MEM-43.