CD58 (LFA-3) Mouse anti-Human, APC, Clone: TS2/9, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0578-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15517956

Quantity Price
1 £ 155.16 / 100 tests
Estimated Shipment date
from Supplier 04-05-2017
Add to basket


Description and Specification

Specification

Isotype IgG1
Conjugate APC
Quantity 100 tests
Primary or Secondary Primary
Host Species Mouse
Applications Flow Cytometry
Format Conjugated
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone TS2/9
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.5μg)/test
Antigen CD58 (LFA-3)

The TS2/9 antibody recognizes human CD58, which is also known as Lymphocyte Associated Antigen-3 (LFA-3). CD58 exists both as a transmembrane protein as well as a GPI-linked extracellular protein. It has been shown that cells can express both forms concurrently. In addition, soluble CD58 has also been observed in serum, urine and synoval fluid of rheumatoid arthritis patients. CD58 is found on non-hematopoietic and most hematopoietic cells. Binding to its ligand CD2, which is present on T cells, initiates a signaling pathway which includes phosphorylation and results in release of cytokines. CD58 has been shown to be important in adhesion to various cell types, T cell activation, cytokine production and cytoxicity.
The TS2/9 antibody has been reported to induce signaling events upon crosslinking. The epitope is in domain 1 of the immunoglobulin region.