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CD58 (LFA-3) Mouse anti-Human, APC, Clone: TS2/9, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-0578-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15507956

  • £61.11 / 25 tests


EU Stock 2
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Disclaimers:

For Research Use Only.


Description

Description

The TS2/9 antibody recognizes human CD58, which is also known as Lymphocyte Associated Antigen-3 (LFA-3). CD58 exists both as a transmembrane protein as well as a GPI-linked extracellular protein. It has been shown that cells can express both forms concurrently. In addition, soluble CD58 has also been observed in serum, urine and synoval fluid of rheumatoid arthritis patients. CD58 is found on non-hematopoietic and most hematopoietic cells. Binding to its ligand CD2, which is present on T cells, initiates a signaling pathway which includes phosphorylation and results in release of cytokines. CD58 has been shown to be important in adhesion to various cell types, T cell activation, cytokine production and cytoxicity.
The TS2/9 antibody has been reported to induce signaling events upon crosslinking. The epitope is in domain 1 of the immunoglobulin region.
Specifications

Specifications

CD58 (LFA-3)
TS2/9
APC
Conjugated
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
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