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CD54 (ICAM-1) Rat anti-Mouse, Clone: KAT-1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-0542-81

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258477

  • £60.53 / 50µg


Estimated Shipment
07-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The eBioKAT-1 monoclonal antibody reacts with mouse CD54 (ICAM-1), which is a 95kDa member of the immunoglobulin superfamily. CD54 is expressed at low levels on leukocytes and high endothelial venules, and expression increases in response to inflammatory cytokines. ICAM-1 binds to LFA-1 and this interaction is required for the transendothelial migration of T cells. ICAM-1-deficient mice are viable, however the migration of leukocytes to sites of inflammation is reduced leading to impaired immune and inflammatory responses. Based on the regulated expression of ICAM-1, it has been suggested that ICAM-1 may increase leukocyte extravasation at sites of inflammation, whereas the constitutively high expression of ICAM-2 mediates leukocyte traffic into non-inflamed tissue. The eBioKAT-1 monoclonal antibody recognizes a different epitope than the YN1/1.7.4 monoclonal antibody.
Description & Specifications

Specifications

CD54 (ICAM-1)
KAT1)
Unlabeled
aqueous buffer, no sodium azide
Rat
50μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
1mg/mL
Purified
Intercellular adhesion molecule-1
IgG2a
RUO
Primary
Murine