CD54 (ICAM-1) Rat anti-Mouse, Clone: KAT-1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0542-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227027

Quantity Price
1 £ 109.45 / 500µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Regulatory Status RUO
Primary or Secondary Primary
Concentration 0.5mg/mL
Conjugate Unlabeled
Clone KAT1)
Host Species Rat
Format Purified
Isotype IgG2a
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Species Reactivity Mouse
Antigen CD54 (ICAM-1)
Gene Alias Intercellular adhesion molecule-1, ICAM1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 500μg

The eBioKAT-1 monoclonal antibody reacts with mouse CD54 (ICAM-1), which is a 95kDa member of the immunoglobulin superfamily. CD54 is expressed at low levels on leukocytes and high endothelial venules, and expression increases in response to inflammatory cytokines. ICAM-1 binds to LFA-1 and this interaction is required for the transendothelial migration of T cells. ICAM-1-deficient mice are viable, however the migration of leukocytes to sites of inflammation is reduced leading to impaired immune and inflammatory responses. Based on the regulated expression of ICAM-1, it has been suggested that ICAM-1 may increase leukocyte extravasation at sites of inflammation, whereas the constitutively high expression of ICAM-2 mediates leukocyte traffic into non-inflamed tissue. The eBioKAT-1 monoclonal antibody recognizes a different epitope than the YN1/1.7.4 monoclonal antibody.