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CD51/CD61 (Integrin alpha v beta 3) Monoclonal Antibody (23C6), FITC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£64.00 - £150.00

Specifications

Antigen CD51/CD61 (Integrin alpha v beta 3)
Clone 23C6
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15566416
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Affymetrix eBioscience
11-0519-41
25 Tests
£64.00
25 tests
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Estimated Shipment: 07-05-2024
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15576416
View Documents Promotion Details
Affymetrix eBioscience
11-0519-42
100 Tests
£150.00
100 tests
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Estimated Shipment: 07-05-2024
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Description

Description

Description: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. CD51, an ∽120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by melanoma cells, endothelial cells and osteoclasts and at very low levels by platelets. The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin. Applications Reported: The 23C6 antibody has been reported for use in flow cytometric analysis. Applications Tested: The 23C6 antibody has been pre-titrated and tested by flow cytometric analysis of human melanoma cell line and peripheral blood cells. This can be used at 5 μL (1 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
Specifications

Specifications

CD51/CD61 (Integrin alpha v beta 3)
5 μL/Test
Monoclonal
Liquid
RUO
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
1110004F14Rik; 2610028E01Rik; alpha v integrin; antigen CD61; antigen identified by monoclonal antibody L230; BDPLT16; BDPLT2; Cd51; CD61; D430040G12Rik; Dnmt3l-ps1 pseudogene; GP3A; GPIIIa; GT; INGRB3; integrin; integrin alpha V; integrin alpha-5 beta-3; integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin alphaVbeta3; Integrin beta; integrin beta 3; integrin beta 3 (Cd61); Integrin beta3; integrin beta-3; integrin subunit alpha V; integrin subunit beta 3; integrin, alpha V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGAV; Itgb3; MSK8; platelet gpIIIa; platelet membrane glycoprotein IIIa; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor alpha subunit; vitronectin receptor subunit alpha; VNRA; VTNR
ITGAV, ITGB3
Primary
4° C, store in dark, DO NOT FREEZE!
23C6
Flow Cytometry
FITC
Mouse
Human
P05106, P06756
3685, 3690
IgG1 κ
Affinity chromatography
Antibody
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