CD51/CD61 (Integrin alpha v beta 3), clone: 23C6, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-0519-80
Code : Z2
Additional Details : Weight : 0.01000kg
DescriptionDescription: The 23C6 monoclonal antibody reacts with the human CD51/CD61 dimer, also known as the integrin alphav/beta3. CD51, an ∽120kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by melanoma cells, endothelial cells and osteoclasts and at very low levels by platelets. The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin.Applications Reported: The 23C6 antibody has been reported for use in flow cytometric analysis, and immunohistochemical staining of frozen tissue sections. 23C6 has also been reported in blocking of some adhesive processes. (Please use Functional Grade purified 23C6 in functional assays.).Applications Tested: The 23C6 antibody has been tested by flow cytometric analysis of human melanoma cell line and peripheral blood. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
|CD51/CD61 (Integrin alpha v beta 3)|
|PBS with 0.09% sodium azide; pH 7.2|
|ITGAV, ITGB3, CD51, MSK8, VNRA, VTNR, integrin alpha-V, integrin alphaVbeta3, antigen CD51, vitronectin receptor subunit alpha, CD61, GP3A, GPIIIa|
|Store at 2-8°C.|
For Research Use Only.