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CD49e (Integrin alpha 5) Mouse anti-Human, PE, Clone: P1D6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-4900-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586986

  • £72.77 / 25 tests


Estimated Shipment date
from Supplier 24-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This P1D6 monoclonal antibody reacts with human CD49e, which is also known as integrin alpha 5. Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, α and β. Integrin alpha 5 is expressed on thymocytes, T cells, monocytes, platelets, as well as early and activated B cells. Integrins are also expressed on non-hematopoietic and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 5 undergoes post-translational cleavage in its extracellular domain to produce disulfide-linked light and heavy chains that associate with the common beta 1 subunit to form the fibronectin receptor. Studies have demonstrated the involvement of this integrin in cell adhesion, signaling, and apoptosis.

The P1D6 monoclonal antibody has been reported to have blocking activity. Crossblocking studies indicate that P1D6 and eBioSAM-1 recognize a similar epitope.
Specifications

Specifications

CD49e
P1D6
PE
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
ITGA5, VLA-5, Fibronectin receptor
IgG3
RUO
Primary
Human
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