CD49e (Integrin alpha 5) Mouse anti-Human, PE, Clone: P1D6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-4900-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586986

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Host Species Mouse
Antigen CD49e (Integrin alpha 5)
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Quantity 25 tests
Concentration 5μL (0.25μg)/test
Primary or Secondary Primary
Applications Flow Cytometry
Conjugate PE
Format Conjugated
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Isotype IgG3
Gene Alias ITGA5, VLA-5, Fibronectin receptor
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone P1D6

This P1D6 monoclonal antibody reacts with human CD49e, which is also known as integrin alpha 5. Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, α and β. Integrin alpha 5 is expressed on thymocytes, T cells, monocytes, platelets, as well as early and activated B cells. Integrins are also expressed on non-hematopoietic and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 5 undergoes post-translational cleavage in its extracellular domain to produce disulfide-linked light and heavy chains that associate with the common beta 1 subunit to form the fibronectin receptor. Studies have demonstrated the involvement of this integrin in cell adhesion, signaling, and apoptosis.

The P1D6 monoclonal antibody has been reported to have blocking activity. Crossblocking studies indicate that P1D6 and eBioSAM-1 recognize a similar epitope.