CD49e (Integrin alpha 5) Armenian Hamster anti-Mouse, Rat, FITC, Clone: eBioHMa5-1 (HMa5-1), eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-0493-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15298109

Quantity Price
1 £ 55.0 / 50µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Species Reactivity Mouse, Rat
Primary or Secondary Primary
Isotype IgG
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 50μg
Antigen CD49e (Integrin alpha 5)
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 0.5mg/mL
Host Species Armenian Hamster
Monoclonal or Polyclonal Monoclonal
Clone eBioHMa5-1 (HMa5-1)
Regulatory Status RUO
Conjugate FITC
Gene Alias Integrin a5, ITGA5, VLA5A
Applications Flow Cytometry

The eBioHMα5-1 monoclonal antibody reacts with mouse and rat CD49e, also known as integrin α5 or VLA-5A. CD49e is a member of the integrin α chain family, and binds with CD29 (integrin β1) to form the receptor VLA-5, which binds the ligands fibronectin and fibrinogen. CD49e is a type I, single-pass membrane protein, with a molecular weight of 135 kDa, and is expressed on multiple cell types including thymocytes, mast cells, activated T cells and splenic B cells. In addition to its role in adhesion, VLA-5 contributes to T-cell co-stimulation. The eBioHMα5-1 monoclonal antibody has been demonstrated to interfere with VLA-5-mediated cell adhesion, and with the degranulation of IgE-sensitized rat RBL cells stimulated on fibronectin-coated plates. Furthermore, HMα5-1 injected into mice subcutaneously, along with anti-CD49d and anti-CD61, is able to inhibit passive cutaneous anaphylaxis.