CD49e (Integrin alpha 5) Armenian Hamster anti-Mouse, Rat, Clone: eBioHMa5-1 (HMa5-1), eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0493-81

50UG:ANTI-MOUSE/RAT CD49E(INTEGRIN ALPHA

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15207007

Quantity Price
1 £ 82.0 / 50µg
Estimated Shipment date
from Supplier 23-01-2017
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Description and Specification

Specification

Antigen CD49e (Integrin alpha 5)
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Clone eBioHMa5-1 (HMa5-1)
Concentration 0.5mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Integrin a5, ITGA5, VLA5A
Host Species Armenian Hamster
Isotype IgG
Quantity 50μg
Regulatory Status RUO
Species Reactivity Mouse, Rat
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The eBioHMα5-1 monoclonal antibody reacts with mouse and rat CD49e, also known as integrin α5 or VLA-5A. CD49e is a member of the integrin α chain family, and binds with CD29 (integrin β1) to form the receptor VLA-5, which binds the ligands fibronectin and fibrinogen. CD49e is a type I, single-pass membrane protein, with a molecular weight of 135 kDa, and is expressed on multiple cell types including thymocytes, mast cells, activated T cells and splenic B cells. In addition to its role in adhesion, VLA-5 contributes to T-cell co-stimulation. The eBioHMα5-1 monoclonal antibody has been demonstrated to interfere with VLA-5-mediated cell adhesion, and with the degranulation of IgE-sensitized rat RBL cells stimulated on fibronectin-coated plates. Furthermore, HMα5-1 injected into mice subcutaneously, along with anti-CD49d and anti-CD61, is able to inhibit passive cutaneous anaphylaxis.