CD49e (Integrin alpha 5) Armenian Hamster anti-Mouse, Rat, Clone: eBioHMa5-1 (HMa5-1), eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0493-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15207007

Quantity Price
1 £ 54.42 / 50µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Format Purified
Antigen CD49e (Integrin alpha 5)
Host Species Armenian Hamster
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Isotype IgG
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone eBioHMa5-1 (HMa5-1)
Storage Requirements Store at 2-8°C.
Conjugate Unlabeled
Species Reactivity Mouse, Rat
Monoclonal or Polyclonal Monoclonal
Gene Alias Integrin a5, ITGA5, VLA5A
Concentration 0.5mg/mL
Quantity 50μg
Regulatory Status RUO

The eBioHMα5-1 monoclonal antibody reacts with mouse and rat CD49e, also known as integrin α5 or VLA-5A. CD49e is a member of the integrin α chain family, and binds with CD29 (integrin β1) to form the receptor VLA-5, which binds the ligands fibronectin and fibrinogen. CD49e is a type I, single-pass membrane protein, with a molecular weight of 135 kDa, and is expressed on multiple cell types including thymocytes, mast cells, activated T cells and splenic B cells. In addition to its role in adhesion, VLA-5 contributes to T-cell co-stimulation. The eBioHMα5-1 monoclonal antibody has been demonstrated to interfere with VLA-5-mediated cell adhesion, and with the degranulation of IgE-sensitized rat RBL cells stimulated on fibronectin-coated plates. Furthermore, HMα5-1 injected into mice subcutaneously, along with anti-CD49d and anti-CD61, is able to inhibit passive cutaneous anaphylaxis.