CD49d (Integrin alpha 4) Mouse anti-Rat, APC, Clone: MRa4-1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-1490-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15558016

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Gene Alias ITGA4
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Clone MRa4-1
Quantity 100μg
Antigen CD49d (Integrin alpha 4)
Conjugate APC
Concentration 0.2mg/mL
Regulatory Status RUO
Host Species Mouse
Isotype IgG2a
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Rat

The MRa4-1 monoclonal antibody reacts with CD49d, which is also known as the integrin alpha 4 subunit. This 150kDa cell surface protein is expressed by thymocytes, peripheral lymphocytes, monocytes, and eosinophils in complex with either integrin beta1 or integrin beta7. Outside of the immune system, CD49d is also expressed on mast cells, neural crest cells, retinal cells, and dorsal root ganglion neurons. Integrins are responsible for lymphocyte homing to Peyer’s patches and mesenteric lymph nodes, as well as neural development and regeneration. Several ligands have been reported for the integrin a4b1 complex, including VCAM-1 (CD106) and fibronectin.

The MRa1-4 antibody has been reported to inhibit fibronectin binding and lymphocyte migration.