CD49c (Integrin alpha 3) Mouse anti-Human, APC, Clone: P1B5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0494-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15517946

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Description and Specification

Specification

Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Format Conjugated
Antigen CD49c (Integrin alpha 3)
Concentration 5μL (0.125μg)/test
Species Reactivity Human
Quantity 100 tests
Host Species Mouse
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate APC
Gene Alias VLA3, ITGA3
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG1
Clone P1B5

This P1B5 monoclonal antibody reacts with human CD49c (also known as Integrin alpha 3). Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, α and β. Integrins are expressed on hematopoietic, non-hematopoietic, and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 3 forms a complex with the common beta 1 subunit to form the α3β1 integrin. Studies have demonstrated the involvement of this integrin in wound healing and epithelial migration.

The P1B5 monoclonal antibody has been reported to affect adhesion to type I and VI collagens, as well as fibronectin and laminin.